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Please use this identifier to cite or link to this item: http://hdl.handle.net/10455/2935

Title: Implementation of a Functional Semantic Similarity Measure between Gene-Products
Authors: Couto, Francisco M.
Silva, Mário J.
Coutinho, Pedro M.
Keywords: 
Issue Date: Nov-2003
Publisher: Department of Informatics, University of Lisbon
Series/Report no.: di-fcul-tr-03-29
Abstract: Sequence similarity is a common technique to compare gene-products. However, many applications need to compare gene-products based on what they do, not how they are. Most gene-products are being annotated with terms describing their biological function. These terms are defined in biological ontologies. This makes it possible to implement similarity measures between gene-products based on their behavior. We define FuSSiMeG, a functional similarity measure between gene-products that compares the semantic similarity between the terms in their annotations. Software available from http://xldb.fc.ul.pt/rebil/ssm/
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